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Breast Cancer Pathway Illustration Breast-Cancer-Pathway

Breast Cancer Pathway Illustration

This illustration is an overview of the key molecules involved in breast cell proliferation and cancer. The restriction point represents a key moment in the cell cycle where cell proliferation can be terminated.

JAK/STAT Pathway JAK-STAT-Pathway

JAK/STAT Pathway

The JAK/STAT pathway is involved in gene transcription and as a result is involved in certain cancers. In this image, the transmembrane receptor on the left has been bound by a cytokine which has activated the green JAK proteins. These proteins in turn activate the STAT proteins below.

Blood Brain Barrier Illustration Blood-Brain

Blood Brain Barrier Illustration

This editorial image was created to describe the challenges of delivering an antibody therapeutic across the blood brain barrier.

Laser Treatment (Glaucoma) laser-treatment-glaucoma

Laser Treatment (Glaucoma)

This image was produced to illustrate the mechanism of laser treatment for narrow-angle glaucoma. Lasers are used to make a small opening in the peripheral iris (blue), altering the fluid dynamics within the eye and relieving intraocular pressure.

Peyronie’s Cross Section Penis-Cross-Section

Peyronie’s Cross Section

Peyronie’s disease is caused by plaque in the penile tissue. The light beige tissue is the tunica albuginea. It surrounds the corpora cavernosa, and in this condition, it is chronically inflamed.

Tissue Layers of the Colon Tissue-Layers-of-the-Colon

Tissue Layers of the Colon

This is a microscopic section of colon tirssue. In the mucosa, there are long crypts which contain goblet cells. Beneath that layer, there is muscularis mucosae, submucosa, circular muscle, longtitudicnal muscle, and serosa.

Kinesin Motor Protein with Vesicle Kinesin-Motor-Protein-with-Vesicle

Kinesin Motor Protein with Vesicle

Antibody Drug Conjugate Antibody-Drug-Conjugate

Antibody Drug Conjugate

This antibody drug conjugate was engineered to selectively deliver a cytotoxic agent to a tumor cell. It consits of an antibody made for a specific target molecule, a linker protein, and the cytotoxic agent.

Bacteria Bacterium

Bacteria

E. coli bacteria are often portrayed in a negative light. However, in 1973, Herbet Boyer and Stanley Cohen used E. coli as a vehicle to develop recombinant DNA technology. By inserting plasmids with foreign DNA into E. coli, they showed that genetic materials could be transferred between species.

SWI/SNF Subunits SWI-SNF-Subunits

SWI/SNF Subunits

This image was published with an article detailing the action of a protein complex called SWI/SNF. The complex interacts with histone nucleosomes to open the structure of the chromatin.

PRC2 Activity PRC2-Activity

PRC2 Activity

This illustration was created for a publication describing the catalytic reactions of polycomb repressive complex 2 (PRC2).

Intracellular Activity Intracellular-Activity

Intracellular Activity

Microarray Microarray

Microarray

Featured as a cover on Nature, this image depicts microarray technology for the measurement of gene expression. Single-stranded probes are fixed along a chip and allowed to hybridize with samples. Expression data is collected electronically.

Packed Neurons Packed-Neurons

Packed Neurons

This illustration depicts pyramidal neurons. The bulbous protrusions on the dendrites are called dendritic spines, and dendrites can contain hundreds to thousands of them.

Colorectal Cancer Progression Colorectal-Cancer-Progression

Colorectal Cancer Progression

From left to right, this illustration shows the progression of colorectal cancer on the intestinal wall. It highlights the normal mucosa, aberrant crypt foci, a small polyp, larger polyps, and invasive cancer.

Illuminate Cancer Biology illuminate-cancer-biology

Illuminate Cancer Biology

Bone Marrow Bone-Marrow

Bone Marrow

The bone marrow produces blood cells, which are exported to the rest of the body through the vasculature present in the bone marrow.

Pericyte on Capillary Pericyte-on-Capillary

Pericyte on Capillary

Pericytes are contractile cells with a “spider-like” shape found on the outside of the small vasculature. Pericytes play important roles in regulating capillary blood flow and are also responsible for maintaining permeability of the blood-brain barrier.

Childhood Immunity Childhood-Immunity

Childhood Immunity

RNA Interference (RNAi) RNA-Interference-RNAi

RNA Interference (RNAi)

RNA Interference (RNAi) is a method of regulating gene expression by inhibiting the translation of messenger RNA, primarily by miRNA and siRNA molecules. This biological process is important for resisting certain viral infections, as well as regulating the production of proteins.

Pathway to Insomnia Pathway-to-Insomnia

Pathway to Insomnia

This illustration depicts some of the major signaling pathway associated with the development of insomnia.

Dendritic Cell Dendritic-Cell

Dendritic Cell

Dendritic cells are critical cells in the immune response. They capture antigens, process them, and present them on their cell surfaces. This presentation can activate T cells, which begin a fully mounted defense against the antigen.

Synaptic Vesicle Synaptic-Vesicle

Synaptic Vesicle

Synaptic vesicles are sphere-like structures with that measure about 40 nanometers in diameter. The vesicles encapsulate neurotransmitters that carry signals across neuronal synapses.

Lice Lice

Lice

Immunotherapy Illustration Immunotherapy

Immunotherapy Illustration

This illustration shows the sequence of T cell activation. In the upper left the T cell is inactive. Following that, it connects to an antigen presenting cells. This activates the T cell, enabling it to fight a cancer cell in the lower right.

V.A.C.® Therapy for Wound Healing v.a.c.-therapy-for-wound-healing

V.A.C.® Therapy for Wound Healing

This illustration was developed for KCI to illustrate how their proprietary V.A.C® Therapy help promotes wound healing. Negative pressure applied on the wound site removes infectious material and encourages active granulation.

Mitochondria Mitochondria

Mitochondria

Mitochondria are famous for being the power houses of the cell. While they are known most for manufacturing energy, they are also involved in cell growth and cell death.

Ion Transport Proteins ion-transport-proteins

Ion Transport Proteins

In response to extracellular hypotonicity, KCC3 cotransporter proteins are activated on the surface of red blood cells, forcing an efflux of ions across the cellular membrane. In this image, KCC3 channels are depicted in blue and embedded within the cell membrane (red). This illustration was featured on the cover of Cell.

Targeted Therapeutic Drug Candidates for Cancer targeted-therapeutic-drug-candidates-for-cancer

Targeted Therapeutic Drug Candidates for Cancer

For XCOVERY, we developed an illustration depicting several different pathways involved in the development of cancer, providing insight into potential drug targets.

CD200 Expression CD200-Expression

CD200 Expression

CD200 is a surface-cell marker that is purported to play a role in activating immune suppression. Understanding these pathways may provide insight into potential targets for the treatment of certain cancers.

Normal Eye Anatomy Normal-Eye-Anatomy

Normal Eye Anatomy

This simple illustration shows a basic cross-section of a normal eye.

Cross Section of Wrinkled Skin Cross-Section-of-Wrinkled-Skin

Cross Section of Wrinkled Skin

Physiology of Constipation Physiology-of-Constipation

Physiology of Constipation

Clathrin Uncoating Clathrin-Uncoding

Clathrin Uncoating

Clathrin proteins are involved in building coats for small vesicles. In this image, the clathrin proteins are unraveling to release the vesicle and its contents.

Anti-inflammatory Microbiome Anti-Inflammatory-Microbiome

Anti-inflammatory Microbiome

Colonic bacteria can be anti-inflammatory or pro-inflammatory. This illustration was made to detail the anti-inflammatory signaling and cellular interactions that can mitigate colorectal carcinogenesis.

Biochip Biochip

Biochip

Biochips allow researchers to screen biochemical samples across a large number of simultaneous reactions. These 2-dimensional physical chips can be purposed for DNA analysis, protein analysis, chemical screens, and more.

Protein Ribbon Structure tRNA

Protein Ribbon Structure

Proteins can be depicted in several ways to best illustrate their structure. In the center of the protein, we reveal the ribbon structure that describes the simplified path and organization of the protein.

Calcium Gate Calcium-Gate

Calcium Gate

Bacteriophage Robot Bacteriophage-Robot

Bacteriophage Robot

Bacteriophages are viruses that infect bacteria. This imaginative illustration depicting a bacteriophage with a robot skeleton was developed for a journal cover.

Bladder Anatomy Bladder-Anatomy

Bladder Anatomy

The urinary bladder is innervated by both sympathetic fibers and parasympathetic fibers making the bladder both autonomically and voluntarily controlled. Therefore, nerves associated with the bladder are important targets in urinary conditions, such as incontinence and nocturia.