In collaboration with Global Blood Therapeutics, our folks here at XVIVO created this medical animation to illustrate the mechanism of action of a potential drug candidate for the treatment of sickle cell disease (SCD). SCD is caused by a point mutation in the hemoglobin gene, resulting in the aggregation and polymerization of deoxygenated hemoglobin. This causes structural deformation of red blood cells into the characteristic “sickle” shape, which can lead to cellular lysis and vaso-occlusion, impairing oxygen delivery and causing a number of health effects. Voxelotor is an investigational disease-modifying drug that binds to hemoglobin and increases its affinity to oxygen, keeping it in its oxygenated state. By diluting the concentration of deoxygenated hemoglobin, mutant hemoglobin may be kept from polymerizing, thus preventing cellular sickling and its many clinical consequences.
In partnership with Wedgewood Communications, XVIVO developed two videos for Takeda Oncology to discuss lung cancer…
Coronary heart disease, or CHD, is a leading cause of death in men and women, effecting an estimated 16.5 million…
XVIVO partnered with Symic Bio to develop an animation that demonstrates the potential efficacy of their molecule, SB-030. SB-030 is…
Fibrodysplasia ossificans progressiva, or FOP, is an extremely rare and debilitating disorder, in which bone tissue gradually replaces soft tissue…
About 50,000 people in the United States are diagnosed with IPF each year. After diagnosis, the estimated survival is only…
ABT-199/GDC-0199 is a small molecule drug in co-development by Abbvie and Genentech for the selective inhibition of BCL-2, a key…
In 2006, Harvard University teamed up with XVIVO to develop an animation that would take their cellular biology students on…
XVIVO partnered with Lexicon Pharmaceuticals to create a series of high end medical animations that provide an overview of carcinoid…
The XVIVO team collaborated on a project with Dr. Daniela Nicastro, Associate Professor at the University of Texas Southwestern Medical…
Revolutionizing the imaging capacity of data, Nikon Instruments Inc is proud to unveil the new Eclipse Ti2 Inverted Research Microscope….
By age 50, over half of all males will experience some hair loss caused by Androgenetic Alopecia, also known as…
XVIVO and Novocure have teamed up to illustrate their breakthrough technology for the non-invasive treatment of solid tumors. Tumor Treating…
About 456,000 new cases of esophageal cancer occur each year. In the United States alone, there are 17,000 new cases….
If there’s any person that should be credited with saving millions of lives (and counting), it would be Dr. Maurice…
XVIVO was approached by the NIH (National Institutes of Health) to help raise awareness of extracellular RNA (exRNA). After working…
DNA in the nuclear environment is tightly packed in structures known as nucleosomes, which consist of DNA wound around histone…
Glioblastoma multiforme is considered one of the most aggressive cancers, with an estimated 5-year survival rate of less than 5%….
Harvard University and XVIVO come together again to add to the growing series of scientific animations for BioVisions – Harvard’s…
Together with Peregrine, we helped depict the mechanism of action behind Bavituximab, an investigational treatment that helps the body recognize cancer cells. Upregulated…
The blood-brain barrier (BBB) is a highly selective membrane system that prevents unwanted passage of molecules into the brain extracellular…
These clips come from a project we developed that discuss the mechanisms of disease of Chronic Idiopathic Constipation (CIC) and…
Neonatal respiratory distress syndrome (RDS) is caused by inadequate surfactant production within the underdeveloped lung, which may result in atelectesis….
Many pharmaceuticals create drugs out of a uniform batch of chemically-tailored molecules that are aggregated into pills with a binder,…
Purification is a critical step in drug manufacturing, helping to minimize the incorporation of unwanted materials that can be hazardous…
Working with MELA Sciences, we designed this medical animation to help doctors and their patients understand the underlying cause of…
Organogenesis partnered with XVIVO to help them bring their first product for dental surgery into market. GINTUIT™ (Allogeneic Cultured Keratinocytes…
Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis….
This animation, developed for the International AIDS Vaccine Initiative, demonstrates how an AIDS vaccine might work in the body. Created for…
PDL BioPharma asked XVIVO to show how a novel humanized antibody, HuLuc 63, appears to induce anti-tumor effects by binding…
This animation was developed for use as a 3D stereoscopic projection. This video depicts the mechanism of disease for IEED…
For Incyte, XVIVO developed a chaptered animation program on the JAK signaling pathway. Janus kinases (JAK) are enzymes that mediate…
This science animation was developed for Zirus, a biopharmaceutical company that was working on the development of a new class…
As our country, and world, continues to grapple with issues of social inclusion, our studio has decided to reissue one…
Medtronic Sacral Neuromodulation is a treatment option for patients with overactive bladder (OAB). This 3D medical animation shows dysfunction to…
XVIVO teamed up with Harvard to develop a 3D animation for their Molecular and Cellular Biology students about the microscopic world…
Terumo BCT partnered with XVIVO to develop a program for one of their devices, the Quantum Cell Expansion System. We…
ATryn® (also known as ATIII) is a recombinant form of human antithrombin. This product demonstrates the high potential for the…
Understanding the genetic alterations that underlie cancers may help the development of treatments regardless of tumor location within the body….
Traditional methods of proteomic discovery and analysis involve breaking and rebuilding samples. Snapshot Proteomics™ by AVMBioMed provides for the high-throughput…
Strattice™ Reconstructive Tissue Matrix is a tissue matrix used to support soft tissue regeneration post-surgery. The matrix allows for rapid…
Prevention Pharma partnered with XVIVO to communicate the science behind their product, OMAX3 The Ultra-Pure Omega-3 Supplement. The animation explains the…
Hyponatremia is a condition characterized by low sodium concentration in blood serum. This may be caused by overactivity of anti-diuretic…
From the Caryl and Israel Englander Institute for Precision Medicine website: “Organoids can be made to resemble organs or tissues…
Glutamate is the most abundant excitatory neurotransmitter in the brain. Release of glutamate is essential for normal function of neurons,…
Alain Viel PhD, Senior Lecturer and Director of Undergraduate Research in Molecular and Cellular Biology, Harvard UniversityI was impressed by the ability of the XVIVO team to transform all the structural information and the very detailed sequence of molecular events that I assembled in a story-board into a visually pleasing work of art.