ANIMATION

Palovarotene MOA

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Fibrodysplasia ossificans progressiva, or FOP, is an extremely rare and debilitating disorder, in which bone tissue gradually replaces soft tissue throughout the body, extending the skeleton and “freezing” patients into position. FOP is an autosomal dominant disorder, and is believed to be caused by a mutation in the ACVR1 gene, which results in constitutively active BMP signaling. Clementia Pharmaceuticals is investigating Palovarotene as a RAR-gamma agonist capable of inhibiting BMP signaling, which may prevent heterotopic ossification and slow the progression of this devastating disease.

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Palovarotene MOA

XVIVO was asked to create an extremely complex but biochemically and biologically accurate animation that depicted the role of neuropeptides in brain plasticity. The final product was astounding — far beyond our expectations. This animation is now being used to educate breast cancer survivors on how cognitive processes are restored after chemotherapy. I would highly recommend XVIVO to others seeking similar products.

Lyn Freeman, Ph.D., CEO, Mind Matters Research, LLC
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