ANIMATION

JAK Pathway Signaling

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For Incyte, XVIVO developed a chaptered animation program on the JAK signaling pathway. Janus kinases (JAK) are enzymes that mediate signaling of several important drivers of myeloproliferative neoplasms (MPNs), other hematological malignancies, and inflammatory diseases. This animation focuses on four JAK enzymes: JAK1, 2, 3 and TYK2. Aberrant activation of the JAK-STAT pathway has been documented in a variety of cancers. This clip illustrates normal JAK pathway activation and the associated downstream signaling.

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Incyte

The creation of truly effective science animations requires a community of scientists and multimedia professionals where mutual trust and respect is a given. The leaders at XVIVO bring the creativity and collaborative spirit necessary to hold such a community together and enable innovation in science visualization.

Robert Lue, Director of Life Sciences Education, Professor of the Practice of Molecular and Cellular Biology, Harvard University
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