ANIMATION

Glutamate Modulation

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Glutamate is the most abundant excitatory neurotransmitter in the brain. Release of glutamate is essential for normal function of neurons, but the levels of this neurotransmitter must be tightly regulated to avoid toxic effects on neurons.

XVIVO partnered with Biohaven to animate the glutamate story. The script details normal glutamate signaling, dysfunctional glutamate signaling and the mechanism of action of Biohaven’s investigational agent trigriluzole, a novel neuroprotective agent to modulate glutamate neurotransmission. Trigriluzole is expected to reduce the neurotoxicity associated with excessive glutamatergic excitation, which is implicated in many disorders involving the central nervous system.

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Glutamate Modulation

I wanted to share with you the news I just heard that the fabulous image you prepared for us has been selected for the cover of Cell! This is wonderful testimony to your talent and ability to rapidly reduce an idea to a stunning illustration. We were particularly impressed with your responsiveness and ability to quickly make significant modifications to meet our external deadlines. Many thanks for all your help, and congratulations!

Richard P. Lifton: Chairman, Yale University Department of Genetics; Sterling Professor of Genetics, Medicine and Molecular Biophysics and Biochemistry; Investigator, Howard Hughes Medical Institute
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