ANIMATION

Gleevec (imatinib) MOA

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Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis. Mutations in Kit that result in constitutive oligomerization in the absence of ligand can drive continuous oncogenic signaling. The majority of gastrointestinal stromal tumor (GIST) cells have been found to present with overactive Kit signaling. Gleevec, or Glivec (imatinib mesylate) competitively binds to the ATP binding pocket of both active and inactive Kit, preventing downstream signaling. Kit inhibition by imatinib may induce both apoptosis and quiescence in KIT+ GIST cells.

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Novartis

The team at XVIVO helped to bring the Quantum Cell Expansion System to life! Their talented group of individuals coalesced to form a responsive, accountable, flexible and creative team that delivered an amazing final product – exceeding our expectations. The first showing of the video to a gathering of senior business leaders within the organization met with kudos and loud applause! We plan to leverage the animation in customer presentations, conferences, and marketing opportunities of all stripes and colors. I would strongly recommend XVIVO and look forward to future projects.

Global Marketing Manager, Quantum Cell Expansion System, CaridianBCT
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