ANIMATION

Gleevec (imatinib) MOA

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Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis. Mutations in Kit that result in constitutive oligomerization in the absence of ligand can drive continuous oncogenic signaling. The majority of gastrointestinal stromal tumor (GIST) cells have been found to present with overactive Kit signaling. Gleevec, or Glivec (imatinib mesylate) competitively binds to the ATP binding pocket of both active and inactive Kit, preventing downstream signaling. Kit inhibition by imatinib may induce both apoptosis and quiescence in KIT+ GIST cells.

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Novartis

While translating verbal concepts and still photographs into persuasive animation that meets the clients expectations can be a difficult process, the XVIVO staff met the challenge. The client felt the animation was so well done, they came back and asked for additional still frames so their sales force could also use them in promoting the Synergy system.

Berger Communications Group, LLC
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