ANIMATION

Gleevec (imatinib) MOA

Share this animation:

Kit is a receptor tyrosine kinase that activates of a number of pathways that direct cell proliferation, survival, and apoptosis. Mutations in Kit that result in constitutive oligomerization in the absence of ligand can drive continuous oncogenic signaling. The majority of gastrointestinal stromal tumor (GIST) cells have been found to present with overactive Kit signaling. Gleevec, or Glivec (imatinib mesylate) competitively binds to the ATP binding pocket of both active and inactive Kit, preventing downstream signaling. Kit inhibition by imatinib may induce both apoptosis and quiescence in KIT+ GIST cells.

Share It:
Contact XVIVO

Client


Novartis

I LOVED XVIVO’s reel. I thought their attention to detail was amazing – the way they took the time to add subtle movements to cell walls or the primary visual was exactly what i was looking for but assumed they were too expensive – to my delight they were well within budget + they were also the clients first choice.

Art Director, DH Art Direction & Design, XCOVERY
Share this animation: