ANIMATION

Chronic Idiopathic Constipation

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These clips come from a project we developed that discuss the mechanisms of disease of Chronic Idiopathic Constipation (CIC) and Irritable Bowel Syndrome with Constipation (IBS-C). This animation depicts the micro-anatomy of the bowel from the level of bowel surface microvilli, down to the traffic of ions and proteins across specialized tight junctions that bind villus cells together.

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I wanted to share with you the news I just heard that the fabulous image you prepared for us has been selected for the cover of Cell! This is wonderful testimony to your talent and ability to rapidly reduce an idea to a stunning illustration. We were particularly impressed with your responsiveness and ability to quickly make significant modifications to meet our external deadlines. Many thanks for all your help, and congratulations!

Richard P. Lifton: Chairman, Yale University Department of Genetics; Sterling Professor of Genetics, Medicine and Molecular Biophysics and Biochemistry; Investigator, Howard Hughes Medical Institute
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