ANIMATION

Apoptosis and BCL-2

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ABT-199/GDC-0199 is a small molecule drug in co-development by Abbvie and Genentech for the selective inhibition of BCL-2, a key regulator of cellular apoptosis. BCL-2, part of the larger BCL-2 family, is responsible for the sequestration of pro-apoptopic proteins along the mitochondrial membrane. Displacement of these proteins from BCL-2 in cancerous cells may prime these cells for apoptosis.

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Abbvie; Genentech

We were very pleased with the final product, the speed at which you team completed the rounds from story board to rough animation/final animation, and the flexibility to change parts of the animation when our client came in with additional changes at the last hour. Our client was also very happy with the final product. In addition, Mike and Roz were very buttoned up with the communication flow, and always available when we needed to discuss changes. It would be my pleasure to provide a recommendation if needed.

Dr. Chris. Tobias, OmniGuide Project, Dudnyk
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