When the Englander Institute for Precision Medicine at Weill Cornell wanted to visualize their research on organoids they turned XVIVO.

For the animation’s visual arc we used 2d cutout cartoons that transition to a vibrant realistic 3d world. This approach reinforced the concept that cells grown flat on the surface of a plastic dish are inadequate compared to the three-dimensional cellular structures of organoids.

From the Caryl and Israel Englander Institute for Precision Medicine website:

“Organoids can be made to resemble organs or tissues such as gut, kidney, pancreas, liver, breast, prostate, and even brain tissue, all complete with accurate micro-anatomy. Due to their amazing ability to self-organize into tissue structures, researchers at Weill Cornell Medicine have developed a way to grow organoid structures that mimic actual patients’ tumors, and allow our researchers to study how different cancers develop, change, and might respond to various drug therapies.

Given that no two cancers are alike, and each has its own unique molecular identity, physician-scientists at the Englander Institute for Precision Medicine at Weill Cornell Medicine and NewYork-Presbyterian Hospital have been using organoids as models to make more precise diagnoses and develop treatments that are based upon the specialized makeup of an individual’s cancer, instead of using a standardized one-size-fits-all approach based upon the location of the disease.

We have received a tremendously enthusiastic response from students, both in freshman biology and sophomore cell biology courses.

Robert Lue, Director of Life Sciences Education, Professor of the Practice of Molecular and Cellular Biology, Harvard University
Share this animation: