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Palovarotene MOA

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Fibrodysplasia ossificans progressiva, or FOP, is an extremely rare and debilitating disorder, in which bone tissue gradually replaces soft tissue throughout the body, extending the skeleton and “freezing” patients into position. FOP is an autosomal dominant disorder, and is believed to be caused by a mutation in the ACVR1 gene, which results in constitutively active BMP signaling. Clementia Pharmaceuticals is investigating Palovarotene as a RAR-gamma agonist capable of inhibiting BMP signaling, which may prevent heterotopic ossification and slow the progression of this devastating disease.

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Palovarotene MOA

XVIVO met our tight publication deadline to produce a colorful, engaging, and accurate illustration of the brain structures children learn about in my foundation’s MindUP program. We are so grateful that XVIVO helped us produce this wonderful resource for the children and their teachers.

Goldie Hawn, Actress, Children’s Advocate, and Founder of The Hawn Foundation
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