For Incyte, XVIVO developed a chaptered animation program on the JAK signaling pathway. Janus kinases (JAK) are enzymes that mediate signaling of several important drivers of myeloproliferative neoplasms (MPNs), other hematological malignancies, and inflammatory diseases. This animation focuses on four JAK enzymes: JAK1, 2, 3 and TYK2. Aberrant activation of the JAK-STAT pathway has been documented in a variety of cancers. This clip illustrates normal JAK pathway activation and the associated downstream signaling.
Alain Viel PhD, Senior Lecturer and Director of Undergraduate Research in Molecular and Cellular Biology, Harvard University
I was impressed by the ability of the XVIVO team to transform all the structural information and the very detailed sequence of molecular events that I assembled in a story-board into a visually pleasing work of art.