Work / Animation / JAK Pathway Signaling
For Incyte, XVIVO developed a chaptered animation program on the JAK signaling pathway. Janus kinases (JAK) are enzymes that mediate signaling of several important drivers of myeloproliferative neoplasms (MPNs), other hematological malignancies, and inflammatory diseases. This animation focuses on four JAK enzymes: JAK1, 2, 3 and TYK2. Aberrant activation of the JAK-STAT pathway has been documented in a variety of cancers. This clip illustrates normal JAK pathway activation and the associated downstream signaling.
William Segraves, Associate Professor Molecular, Cellular and Developmental Biology, Yale University
XVIVO combines exceptional artistic and technical skills with a strong understanding of biology and an exemplary responsiveness to educational needs and objectives.