Work / Animation / Fibroblasts
Oxidative stress in the inflamed wound environment causes premature fibroblast aging, which can lead to the breakdown and insufficient production of the extracellular matrix. The presence of non-senescent fibroblasts can help defend against pathogens in the wound while helping to promote matrix regeneration through the release of signaling factors.These fibroblasts produce molecules including Type I and Type III collagen, fibronectin, and tenascin, which in combination provide structural tissue support while protecting the wound and directly influencing the behavior of nearby cells to promote regeneration.
Account Supervisor, Ogilvy Healthworld
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